In the late 80's George Harrison, Jeff Lynne, Roy Orbison, Tom Petty, and Bob Dylan formed the supergroup Traveling Wilburys.
Here's their original version of Handle With Care, from 1988 (see it on YT here, with better quality):
Here's the version I heard first, by Jenny Lewis, with the Watson Twins, Connor Oberst, M. Ward, and Ben Gibbard, from Jenny's album with the Watson Twins, Rabbit Fur Coat (my faaaaaavorite album ever!):
And here's a video of Jenny with Connor Oberst and Johnathan Rice doing the song live (the sound quality isn't great):
Now, I'm going to go watch this week's True Blood and try to relax.